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Cambridge Isotope Laboratories

Cambridge Isotope Laboratories, Inc. (CIL) is the world’s leading producer of stable isotopes and stable isotope-labelled compounds.

With over 400 employees and laboratories in four countries, CIL specializes in the process of labelling biochemical and organic compounds with highly enriched, stable (non-radioactive) isotopes of carbon, hydrogen, nitrogen and oxygen for use in mass spectrometry (mass spec) or nuclear magnetic resonance (NMR).

Buchem BV is proud distributor for CIL products in the Benelux.

CIL Mass Spectrometry Catalog

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    Metabolic Research

    Researchers employ stable isotope techniques to study a wide variety of metabolic disorders and diseases including Alzheimer’s, Parkinson’s, cancer, diabetes, and obesity.

    Fluxing Through Cancer

    Stable Isotope Labeling Kinetics (SILK™) to Measure the Metabolism of Brain-Derived Proteins Implicated in Neurodegeneration

    Isotopes are most commonly used in metabolism research as tracers to quantify biochemical or metabolic reactions in vivo. They can be used to study metabolic pathways, to determine biomarkers, to test the effects of a drug, and to develop metabolic profiles of biological systems in a particular state.

    CIL offers the most complete listing of stable isotopically labelled metabolic substrates available.

    These metabolic substrates are labelled with 13C, 15N, 18O, D, as well as other stable isotopes. Some of the many applications for these materials include the utilization of amino acids for protein turnover studies, carbohydrates for glucose metabolism studies, and fatty acids for lipolysis research.

    Stable isotope labelling of these materials allows investigators to study metabolic pathways in living systems in a manner which is safe, accurate and non-invasive.

    Isotope-dilution mass spectrometry (IDMS) is inarguably the most accurate, sensitive, reproducible and popular method available for quantifying small and intermediate-sized molecules in a wide range of sample types.

    One primary reason why compounds enriched in stable isotopes make ideal internal standards for comparative or absolute quantitation using mass spectrometry is that separate signals from the “heavy” (isotope enriched) and “light” (native) forms of the same compound are detected simultaneously.

    Stable Isotopes for Metabolomics

    Stable Isotopes in Drug Development and Personalized Medicine: Biomarkers that Reveal Causal Pathway Fluxes and the Dynamics of Biochemical Networks

    CIL provides additional testing to many of our products as a service to our customers. The following documents describe the nature of these products, the different levels of control applied to them, and the Enhanced Technical Data Package that is available for some products.

    Research Use of CIL Products

    Product Quality Designation Chart

    Enhanced Technical Data Package

    Buchem BV is proud distributor for CIL products in the Benelux.

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