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Cambridge Isotope Laboratories

Cambridge Isotope Laboratories, Inc. (CIL) is the world’s leading producer of stable isotopes and stable isotope-labelled compounds.

With over 400 employees and laboratories in four countries, CIL specializes in the process of labelling biochemical and organic compounds with highly enriched, stable (non-radioactive) isotopes of carbon, hydrogen, nitrogen and oxygen for use in mass spectrometry (mass spec) or nuclear magnetic resonance (NMR).

Buchem BV is proud distributor for CIL products in the Benelux.

CIL Mass Spectrometry Catalog

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    With increasing requirements from institutional review boards (IRBs) and governmental agencies, partnering with Cambridge Isotope Laboratories, Inc. (CIL) for your next stable isotope cGMP project can help ensure your regulatory compliance. With the world’s largest 13C and 18O isotope-separation plants, CIL is able to provide the raw materials necessary for your project.

    Your compound of interest most likely already appears in CIL’s extensive list of research compounds – if not, CIL’s team of PhD chemists can determine the best method of synthesis for incorporating 13C, 15N, deuterium, 17O, and/or 18O into your compound.

    CIL has manufactured bulk active pharmaceutical ingredients (APIs) since 1994. It recently added a 15,000-square-foot, state-of-the-art cGMP facility to complement its existing cGMP facilities.

    An additional team of experts – specializing in synthetic chemistry, customer support, quality control, and quality assurance – serves to provide technical guidance from beginning to end of your project.

    Buchem BV is proud distributor for CIL products in the Benelux.

    Fluxing Through Cancer

    Stable Isotope Labeling Kinetics (SILK™) to Measure the Metabolism of Brain-Derived Proteins Implicated in Neurodegeneration

    Stable Isotopes in Drug Development and Personalized Medicine: Biomarkers that Reveal Causal Pathway Fluxes and the Dynamics of Biochemical Networks

    Product Quality Designation Chart


    Manufacturing Capabilities

    • Dedicated development facility

    • Five production and two isolation suites

    • Dedicated packaging room

    • Production scale from milligrams to multikilograms

    • Clinical trials to bulk API

    • Customizable projects to meet your needs


    Analytical Services

    • Fully equipped analytical facility

    • Method development and validation

    • Raw material and final product testing

    • Wet chemistry and compendial methods

    • Stability studies and chambers

    • Dedicated cGMP instruments and facility


    Analytical instrumentation

    •  High-field NMR (1H, D, 13C, 15N, multinuclear)

    • HPLC with UV, RI, ELSD, DA, Pickering, and MS detection

    • GC with FID, ECD, and MS detection

    • KF

    • FT-I

    • Polarimetery

    • TOC


    Quality and Compliance

    • Drug master files

    • FDA-audited facility

    • QA release of API product

    • Follows FDA and ICH guidances

    • CMC sections for NDA or IND

    Please use the search function to find the desired product or contact us for further information.